1. Be ready for changes in the weather
The weather can change dramatically and nowhere will you feel it as
you will on a motorcycle. You will sense the changes from going from
city to woods or rising in elevation, the temperature will drop as you
gain altitude. You'll be glad that you have the proper gear when you
run into it.
2. Make frequent stops and hydrate
Travelling on two wheels is very different from sitting in a car. The winds, vibration, and physical nature of riding will creep into you over time. Make sure you're alert. If you're cramping up take a break. Stop at a gas station and talk to some people. Remember to drink lots of fluids as the winds can help to dehydrate you.
3. Check your motorcycle thoroughly for safety
Click this link: Checklist and go
over a safety check. Make sure your motorcycle is ready and safe. Your
life may depend on it. Get into the habit of going over a mental checklist
when you stop. At the very least check your lights and tires frequently.
4. Start early in the morning
The traffic is lighter in the morning and it will give you more time
for stops along the way. It really is about the trip. Meet people and
see what you've been missing hurrying by in a car. Some of the most
interesting people I've met have been while I was traveling on a motorcycle.
5. Keep your motorcycle clean
Wash your windshield and clean off the bugs and grime. A small oil leak
or damaged parts will reveal itself on a clean bike.
6. Keep your stuff dry!
There's nothing as bad as stopping for the night and finding your clothes and all your gear is soaked. I have a friend that puts things into zip lock freezer bags. Take extra garbage bags and duct tape and cover your gear if it looks like rain.
7. Mail stuff home
No matter how much storage you have on your bike it's never enough for the stuff you pick up on the road. Mail it home. Mail home your dirty laundry. It's a great way to lighten your load and make room for more.
8. Be resourceful
You've got to use all your skills to make your trip a success. Use the rest areas to check the map and look for weather information. Talk to people and ask about the roads. They might even be able to guide you to a new destination.